Electrochemical sensing platform for simultaneous detection of 6-mercaptopurine and 6-thioguanine using RGO-Cu2O/Fe2O3 modified screen-printed graphite electrode

A sensitive electrochemical sensor was developed using reduced graphene oxide RGO-Cu2O/Fe2O3 nanocomposite for 6-mercaptopurine detection based on a facile fabrication method. The surface morphology and structural composition of this evaluated by X-ray diffraction (XRD), field emission scanning electron microscopy (FE-SEM), Fourier transform infrared (FT-IR) spectroscopy. screen-printed graphite electrode (SPGE) modified with (RGO-Cu2O/Fe2O3/SPGE) indicated excellent properties to detect 6-mercaptopurine. linear dynamic range estimated between 0.05 400.0 μM detection, limit 0.03 μM. Also, RGO-Cu2O/Fe2O3/SPGE showed good activity simultaneous 6-thioguanine. In the coexistence system 6-thioguanine, two clear well-isolated voltammetric peaks were obtained differential pulse voltammetry (DPV). Additionally, proposed examined applicability determining 6-thioguanine in real samples, recovery 97.5-103.0 % obtained.